I would suggest downloading Spybot - Search & Destroy 1.4, a program that removes spyware, available from: http://www.pcworld.com/downloads/file_description/0,fid,22262,00.asp
Check for updates before running. If you have trouble getting the updates, near the top of the Update Window, click the little arrow next See-Cure #1(Europe), highlight the next one on the list, See-Cure #2 and try to download the updates. If that doesn't work, try the next one the list. until you get one you can download from. Being a free program, if too many people are using the same site to download the updates, some people will not get them.
After you remove the spyware, open Internet Explorer and reset your homepage. While IE is opened, I would also suggest going to the following site and run a free virus scan: http://security.symantec.com/sscv6/default.asp?langid=ie&venid=sym
Click the GO button, then under Virus Detection, click Start. You might be told that you need to download and install ActiveX Controls for the scan to work, answer Yes.
Write down exactly anything it finds, then go to: http://www.symantec.com/search/
and do a search for what was found. Symantec usually has a removal tool and/or directions for removing manually. Make sure that you follow the instructions for removal, step by step, especially the part regarding disabling System Restore.